[DOWNLOAD] "Biocompatible Nanomaterials for Targeted and Controlled Delivery of Biomacromolecules" by Deepak N. Kapoor & Sanju Dhawan ~ Book PDF Kindle ePub Free

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eBook details

• Title: Biocompatible Nanomaterials for Targeted and Controlled Delivery of Biomacromolecules
• Author : Deepak N. Kapoor & Sanju Dhawan
• Release Date : January 20, 2013
• Genre: Engineering,Books,Professional & Technical,
• Pages : * pages
• Size : 1808 KB

Description

Nanomaterials are organic or inorganic entities employed for the construction

of various nanostructured devices or systems with nanometric dimensions.

These nanostructures may include nanoparticles, nanowires, nanotubes,

nanocapsules, nanocomposites as well as nanoporous solids. Nanomaterials

have gained immense recognition, particularly in biomacromolecular delivery,

owing to their capability of controlling the release rate or targeting the

therapeutic moieties at molecular, cellular and organ level. Additionally,

the problems of conformational and degradation stability associated with

biomacromolecules like peptides, proteins, and genes have been addressed

successfully by employing these nanomaterials. The degradation products

of these biocompatible nanomaterials are non-toxic, non-immunogenic

and easily resorbable by the regular physiological processes. The present

chapter endeavors to describe the role of nanomaterials in the design, fabrication

and development of various nanostructured, biomacromolecular

delivery systems and devices. The chapter presents a discussion on various

physicochemical properties, preparation techniques and analytical tools for

characterizing these systems. The mechanisms of cellular internalization of

nanomaterial based targeted systems are also discussed. Taking lead from

various successful case studies, the present chapter provides a bird’s eye view

on the current advances in the field of nanomaterial based biomacromolecular

delivery. A brief overview pertaining to the regulatory requirements

and commercialization of these systems is also included. Various challenges

posed during the development, scale up and large-scale production is also

discussed. In a nutshell, besides, providing the salient details about the

formulation and applications of biocompatible nanomaterials, the chapter

would act as a ready reference for drug delivery scientists, device fabrication

engineers and medical researchers working in this area.

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